Green Chemistry University Course: Lecture 23 – Molecular Toxicology

This lecture introduces Absorption, Distribution, Metabolism, and Excretion (ADME) concepts and how chemists can take advantage of physicochemical parameters like logP, molecular weight, and vapor pressure to redesign molecules that won’t absorb into the body, limit distribution, and facilitate metabolism and excretion. These concepts are reinforced by an in-class exercise that explores potential absorption routes by benzene. The lecture also explores new approaches to hazard minimization through molecular design.

This course was developed and authored by:

Philip Coish
Kimberly Chapman
Paul Anastas
Seon Augusto Ferreira
Karolina Mellor
Amy Cannon
Derrick Ward